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          <img src="/2025/11/14/20251114-emmaxtwas/index.png" srcset="/img/loading.gif" lazyload alt="什么？EMMAX也能做全转录组关联分析（Transcriptome-wide Association Study，TWAS）">
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          什么？EMMAX也能做全转录组关联分析（Transcriptome-wide Association Study，TWAS）
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          全基因组关联分析从正向遗传学的角度出发，探究“基因型-表型”之间的关联，近年来在人类疾病和作物产量、品质以及抗逆等多方面的遗传机理研究中发挥重要作用。然而由于连锁不平衡（Linkage Disequilibrium，LD）的存在，我们很难直接从 GWAS 结果中找到和表型相关的因果变异（causal variant）或候选基因。尤其在自交作物中，由于 LD 衰减较慢，这一问题更加突出。全转录组关联
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          📌 更新说明（2025-07-31） BackgroundAnalysis.R 中使用的 SNPbinner 改成依赖 python3 的版本。 12# 下载 python3 版本的 SNPbinnergit clone https://github.com/laowang1992/SNPbinner.git  传统育种工作量大、周期长。通过将回交育种与分子标记辅助选择（Marker-Assi
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          Cell | AI 预测蛋白质结构揭示脱氨酶功能及其基因编辑应用
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          脱氨酶（Deaminase）是一类催化核苷酸和碱基脱氨的酶，广泛参与突变、核苷酸代谢以及基因编辑等重要生物学过程。近年来，脱氨酶在单碱基编辑技术中的应用受到了广泛关注。然而，传统的蛋白功能挖掘主要依赖于氨基酸序列信息，难以全面揭示脱氨酶的进化关系和功能特性。 2023 年 7 月，Cell 期刊在线发表了中科院遗传发育所高彩霞团队题为《Discovery of deaminase function
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          <img src="/2025/03/05/20250305-riceRHS12/schematic.jpg" srcset="/img/loading.gif" lazyload alt="Cell | 籼稻粳稻杂种不育分子机理">
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          Cell | 籼稻粳稻杂种不育分子机理
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          水稻（Oryza sativa）是亚洲地区最重要的粮食作物之一，其亚种间的杂交不育问题长期以来限制了杂交优势的利用。籼稻（indica）和粳稻（japonica）作为水稻的两个主要亚种，其杂交后常表现出雄性不育现象，这一现象被认为是物种形成和生殖隔离的重要机制。近年来，研究者们陆续克隆了多个控制水稻杂交不育的基因座，这些基因座通常通过“toxin-antidote”或“killer-protect
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              <a href="/tags/%E6%B0%B4%E7%A8%BB/">#水稻</a>
            
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          甘蓝型油菜（Brassica napus L.）是重要的油料作物之一。已有研究表明，黄籽油菜比黑籽油菜有更高的含油量，同时具有更低木质纤维素含量、皮壳率以及原花青素含量，其生产的菜籽油在市场上更受欢迎。然而具有显性黄籽表型等位基因的种质资源十分稀少，阻碍了黄籽油菜品种的选育。 2025年1月3日，华中科技大学栗茂腾教授和华中农业大学张椿雨教授为共同通讯作者在 Science Advance 期刊发
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              <a href="/tags/%E7%94%98%E8%93%9D%E5%9E%8B%E6%B2%B9%E8%8F%9C/">#甘蓝型油菜</a>
            
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          <img src="/img/index_banner/20241207-mummerCoordsPlot.png" srcset="/img/loading.gif" lazyload alt="R绘图 | mummer比对可视化">
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          📌 更新说明（2025-10-31） mummerCoordsPlot.R 已经整合到 AlignmentDotPlot.R 中，AlignmentDotPlot.R 新增 minimap2 比对结果（paf文件）可视化功能。   The MUMmer system and the genome sequence aligner nucmer included within it are am
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          <img src="/2024/03/15/20240315-ggraster/rastr.svg" srcset="/img/loading.gif" lazyload alt="R绘图 | ggrastr：位图矢量图可以兼得">
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          R 语言绘图导出时我们可以选择矢量图，清晰且放大不失真，但是当图中元素太多时会导致导出文件太大并且打开查看时也不太方便；那么也可以选择位图，不管图中元素有多少，在一定分辨率下图片大小不会有太大差别，但是图中的注释或一些文字信息就会失真。以下面这个曼哈顿图为例，如果全用矢量图那么肯定会给存储、编辑、查看带来不便。一个合理的方案是将图片中主体部分变成位图，也就是栅格化，坐标轴阈值线等等其他部分保持不变
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          好大的一场雪。
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          <img src="/2023/12/22/20231222-JinYongChronicles/OIP.jpg" srcset="/img/loading.gif" lazyload alt="金庸武侠编年史">
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          金庸（原名查良镛，Louis Cha）一共写过十五部武侠小说，其中十四部在《鹿鼎记·后记》中取书名首字总结为一副对联：“飞雪连天射白鹿，笑书神侠倚碧鸳”，再加上一个短篇《越女剑》[1]。 这些小说的版本有连载版、三联版和新修版。  连载版：金庸的武侠小说最初是通过报纸、杂志等媒体逐章连载的，从 1955 年开始写《书剑恩仇录》到 1970 年写《越女剑》，共历时十五年。 三联版：通常也叫做“修订版
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